Ontology highlight
ABSTRACT:
SUBMITTER: Chittum JE
PROVIDER: S-EPMC8525342 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Chittum John E JE Sankaranarayanan Nehru Viji NV O'Hara Connor P CP Desai Umesh R UR
ACS medicinal chemistry letters 20211008 11
SARS-CoV-2 infects human cells through its surface spike glycoprotein (SgP), which relies on host cell surface heparan sulfate (HS) proteoglycans that facilitate interaction with the ACE2 receptor. Targeting this process could lead to inhibitors of early steps in viral entry. Screening a microarray of 24 HS oligosaccharides against recombinant S1 and receptor-binding domain (RBD) proteins led to identification of only eight sequences as potent antagonists; results that were supported by detailed ...[more]