Dataset Information

Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population.

ABSTRACT:

SUBMITTER: Rescenko R

PROVIDER: S-EPMC8526276 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population.

Rescenko Raimonds R Peculis Raitis R Briviba Monta M Ansone Laura L Terentjeva Anna A Litvina Helena Daiga HD Birzniece Liga L Megnis Kaspars K Kolesova Oksana O Rozentale Baiba B Viksna Ludmila L Rovite Vita V Klovins Janis J

Virologica Sinica 20211020 5

PMID: 34668132

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Project description:Genetic and non-genetic factors are responsible for the high interindividual variability in the response to SARS-CoV-2. Although numerous genetic polymorphisms have been identified as risk factors for severe COVID-19, these remain understudied in Latin-American populations. This study evaluated the association of non-genetic factors and three polymorphisms: ACE rs4646994, ACE2 rs2285666, and LZTFL1 rs11385942, with COVID severity and long-term symptoms by using a case-control design. The control group was composed of asymptomatic/mild cases (n = 61) recruited from a private laboratory, while the case group was composed of severe/critical patients (n = 63) hospitalized in the Hospital Universitario Mayor-Méderi, both institutions located in Bogotá, Colombia. Clinical follow up and exhaustive revision of medical records allowed us to assess non-genetic factors. Genotypification of the polymorphism of interest was performed by amplicon size analysis and Sanger sequencing. In agreement with previous reports, we found a statistically significant association between age, male sex, and comorbidities, such as hypertension and type 2 diabetes mellitus (T2DM), and worst outcomes. We identified the polymorphism LZTFL1 rs11385942 as an important risk factor for hospitalization (p < 0.01; OR = 5.73; 95% CI = 1.2-26.5, under the allelic test). Furthermore, long-term symptoms were common among the studied population and associated with disease severity. No association between the polymorphisms examined and long-term symptoms was found. Comparison of allelic frequencies with other populations revealed significant differences for the three polymorphisms investigated. Finally, we used the statistically significant genetic and non-genetic variables to develop a predictive logistic regression model, which was implemented in a Shiny web application. Model discrimination was assessed using the area under the receiver operating characteristic curve (AUC = 0.86; 95% confidence interval 0.79-0.93). These results suggest that LZTFL1 rs11385942 may be a potential biomarker for COVID-19 severity in addition to conventional non-genetic risk factors. A better understanding of the impact of these genetic risk factors may be useful to prioritize high-risk individuals and decrease the morbimortality caused by SARS-CoV2 and future pandemics.

Dataset Information

Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population.

Publications

Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population.

Similar Datasets

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