Ontology highlight
ABSTRACT:
SUBMITTER: Bona R
PROVIDER: S-EPMC8526422 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Bona Roberta R Michelini Zuleika Z Mazzei Chiara C Gallinaro Alessandra A Canitano Andrea A Borghi Martina M Vescio Maria Fenicia MF Di Virgilio Antonio A Pirillo Maria Franca MF Klotman Mary E ME Negri Donatella D Cara Andrea A
Molecular therapy. Methods & clinical development 20211001
Integrase-defective lentiviral vectors (IDLVs) represent an attractive platform for vaccine development as a result of the ability to induce persistent humoral- and cellular-mediated immune responses against the encoded transgene. Compared with the parental integrating vector, the main advantages for using IDLV are the reduced hazard of insertional mutagenesis and the decreased risk for vector mobilization by wild-type viruses. Here we report on the development and use in the mouse immunogenicit ...[more]