A novel prognostic immunoscore based on The Cancer Genome Atlas to predict overall survival in colorectal cancer patients.

ABSTRACT: Colorectal cancer (CRC) is highly prevalent worldwide. The relationship between the infiltration of immunocytes in CRC and clinical outcome has been investigated in recent years. The present study aims to construct a new prognostic signature using an immunocyte panel. Our novel prognostic immunoscore included 13 types of immunocytes, which were identified by least absolute shrinkage and selection operator (LASSO)-Cox regression. The time-dependent receiver operating characteristic (ROC) curve and Kaplan-Meier survival estimates were applied to evaluate the prognostic ability. Compared with the signature based on a single immune marker (i.e., CD8 mRNA expression and CD8+ expressing T cells), the novel prognostic immunoscore possessed better specificity and sensitivity of prognosis (area und

SUBMITTER: Tang Z 

PROVIDER: S-EPMC8529338 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature