Ontology highlight
ABSTRACT:
SUBMITTER: Hachigian T
PROVIDER: S-EPMC8529589 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Hachigian Tim T Lysne Drew D Graugnard Elton E Lee Jeunghoon J
ACS omega 20211007 41
Solution-based biosensors that utilize aptamers have been engineered in a variety of formats to detect a range of analytes for both medical and environmental applications. However, since aptamers have fixed base sequences, incorporation of aptamers into DNA strand displacement networks for feed-forward signal amplification and processing requires significant redesign of downstream DNA reaction networks. We designed a novel aptamer transduction network that releases customizable output domains, w ...[more]