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Relationships between reproductive hormones and maternal pregnancy physiology in women conceiving with or without in vitro fertilization.

ABSTRACT: We evaluated maternal pregnancy adaptations and their relationships with circulating hormones in women who conceived with or without in vitro fertilization (IVF). Pregnancies were grouped by corpus luteum (CL) number: 1 CL with physiological plasma relaxin concentration (P_RLN; spontaneous pregnancies); 0 CL without circulating RLN (programmed cycles); >1 CL with elevated P_RLN (ovarian stimulation). Major findings were that declines in plasma osmolality (P_osm) and plasma sodium concentration ([Formula: see text]) were comparable in the 1 CL and 0 CL cohorts, correlated with plasma estradiol and progesterone concentrations but not P_RLN; gestational declines in plasma uric acid (UA) concentration (P_UA) were attenuated after IVF, especially programmed cycles, partly because of subdued increases of renal UA clearance; and P_RLN and cardiac output (CO) were inversely correlated when plasma estradiol concentration was below ∼2.5 ng/mL but positively correlated above ∼2.5 ng/mL. Unexpectedly, P_RLN and plasma sFLT1 (P_sFLT1) were directly correlated. Although P_sFLT1 and CO were not significantly associated, CO was positively correlated with plasma placental growth factor (PLGF) concentration after the first trimester, particularly in women who conceived with 0 CL. Major conclusions are that 1) circulating RLN was unnecessary for gestational falls in P_osm and [Formula: see text]; 2) P_RLN and CO were inversely correlated during early gestation, suggesting that P_RLN in the lower range may have contributed to systemic vasodilation, whereas at higher P_RLN RLN influence became self-limiting; 3) evidence for cooperativity between RLN and estradiol on gestational changes in CO was observed; and 4) after the first trimester in women who conceived without a CL, plasma PLGF concentration was associated with recovery of CO, which was impaired during the first trimester in this cohort.

SUBMITTER: Conrad KP

PROVIDER: S-EPMC8530757 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Relationships between reproductive hormones and maternal pregnancy physiology in women conceiving with or without in vitro fertilization.

Conrad Kirk P KP Taher Shèdy S Chi Yueh-Yun YY Qiu Yingjie Y Li Mingyue M Lingis Melissa M Williams R Stan RS Rhoton-Vlasak Alice A Keller-Wood Maureen M Segal Mark S MS

American journal of physiology. Regulatory, integrative and comparative physiology 20210804 3

We evaluated maternal pregnancy adaptations and their relationships with circulating hormones in women who conceived with or without in vitro fertilization (IVF). Pregnancies were grouped by corpus luteum (CL) number: 1 CL with physiological plasma relaxin concentration (PRLN; spontaneous pregnancies); 0 CL without circulating RLN (programmed cycles); >1 CL with elevated PRLN (ovarian stimulation). Major findings were that declines in plasma osmolality (Posm) and ...[more]

PMID: 34346723

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Dataset Information

Relationships between reproductive hormones and maternal pregnancy physiology in women conceiving with or without in vitro fertilization.

Publications

Relationships between reproductive hormones and maternal pregnancy physiology in women conceiving with or without in vitro fertilization.

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