Development and Evaluation of a Method for Automated Detection of Spreading Depolarizations in the Injured Human Brain.

ABSTRACT:

Background

Spreading depolarizations (SDs) occur in some 60% of patients receiving intensive care following severe traumatic brain injury and often occur at a higher incidence following serious subarachnoid hemorrhage and malignant hemisphere stroke (MHS); they are independently associated with worse clinical outcome. Detection of SDs to guide clinical management, as is now being advocated, currently requires continuous and skilled monitoring of the electrocorticogram (ECoG), frequently extending over many days.

Methods

We developed and evaluated in two clinical intensive care units (ICU) a software routine capable of detecting SDs both in real time at the bedside and retrospectively and also capable of displaying patterns of their occurrence with time. We tested this protot

SUBMITTER: Jewell S 

PROVIDER: S-EPMC8536628 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature