Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy.

ABSTRACT: The expression of the calcitonin receptor (CT Receptor) is widespread throughout the life cycle of mammals and in many diseases, and in these contexts the functions of the common isoforms is largely unknown. The relatively recent development of anti-CT Receptor antibodies that bind separate epitopes on the CT _a Receptor and CT _b Receptor isoforms has advanced our knowledge and understanding of these events. CT Receptor at the protein level is upregulated in programmed cell death including apoptosis (as described in a previous publication) and autophagy, which is discussed in our upcoming, unpublished review. Incomplete data sets are cited in this review on the upregulation of CACLR (encoding CT Receptor) mRNA, in particular the insert-positive isoform (CT _b

SUBMITTER: Wookey P 

PROVIDER: S-EPMC8543166 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature