Reliability of task-specific neuronal activation assessed with functional PET, ASL and BOLD imaging.

ABSTRACT: Mapping the neuronal response during cognitive processing is of crucial importance to gain new insights into human brain function. BOLD imaging and ASL are established MRI methods in this endeavor. Recently, the novel approach of functional PET (fPET) was introduced, enabling absolute quantification of glucose metabolism at rest and during task execution in a single measurement. Here, we report test-retest reliability of fPET in direct comparison to BOLD imaging and ASL. Twenty healthy subjects underwent two PET/MRI measurements, providing estimates of glucose metabolism, cerebral blood flow (CBF) and blood oxygenation. A cognitive task was employed with different levels of difficulty requiring visual-motor coordination. Task-specific neuronal activation was robustly detected with all thre

SUBMITTER: Rischka L 

PROVIDER: S-EPMC8545051 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature