Sorting nexin 6 interacts with Cullin3 and regulates programmed death ligand 1 expression.
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ABSTRACT:
SUBMITTER: Ghosh C
PROVIDER: S-EPMC8545913 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
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Sorting nexin 6 interacts with Cullin3 and regulates programmed death ligand 1 expression.
Ghosh Chinmoy C Xing Yanli Y Li Suhua S Hoyle Rosalie G RG Sun Ming M Li Jiong J Sun Yue Y
FEBS letters 20210919 20
Programmed death ligand 1 (PD-L1) is critical for the ability of cancer cells to evade attacks by the host immune system. However, the molecular mechanisms controlling PD-L1 expression have not been fully understood. Here, we demonstrate that sorting nexin 6 (SNX6) is a novel regulator of PD-L1 expression. Knockdown of SNX6 in cancer cells significantly decreases PD-L1 protein levels. In contrast, loss of SNX6 does not reduce PD-L1 mRNA levels. Instead, SNX6 interacts with Cullin3, an E3 ubiquit ...[more]
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