Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer.

ABSTRACT: Recent omics analyses of human biofluids provide opportunities to probe selected species of biomolecules for disease diagnostics. Fourier-transform infrared (FTIR) spectroscopy investigates the full repertoire of molecular species within a sample at once. Here, we present a multi-institutional study in which we analysed infrared fingerprints of plasma and serum samples from 1639 individuals with different solid tumours and carefully matched symptomatic and non-symptomatic reference individuals. Focusing on breast, bladder, prostate, and lung cancer, we find that infrared molecular fingerprinting is capable of detecting cancer: training a support vector machine algorithm allowed us to obtain binary classification performance in the range of 0.78-0.89 (area under the receiver operating chara

SUBMITTER: Huber M 

PROVIDER: S-EPMC8547961 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature