Ontology highlight
ABSTRACT:
SUBMITTER: Gagliano O
PROVIDER: S-EPMC8548598 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Gagliano Onelia O Luni Camilla C Li Yan Y Angiolillo Silvia S Qin Wei W Panariello Francesco F Cacchiarelli Davide D Takahashi Joseph S JS Elvassore Nicola N
Nature communications 20211026 1
The circadian system cyclically regulates many physiological and behavioral processes within the day. Desynchronization between physiological and behavioral rhythms increases the risk of developing some, including metabolic, disorders. Here we investigate how the oscillatory nature of metabolic signals, resembling feeding-fasting cycles, sustains the cell-autonomous clock in peripheral tissues. By controlling the timing, period and frequency of glucose and insulin signals via microfluidics, we f ...[more]