Dataset Information

Update on SARS-CoV-2 seroprevalence: regional and worldwide.

ABSTRACT:

Background

With limited vaccine supplies, an informed position on the status of SARS-CoV-2 infection in people can assist the prioritization of vaccine deployment.

Objectives

We performed a systematic review and meta-analysis to estimate the global and regional SARS-CoV-2 seroprevalences around the world.

Data sources

We systematically searched peer-reviewed databases (PubMed, Embase and Scopus), and preprint servers (medRxiv, bioRxiv and SSRN) for articles published between 1 January 2020 and 30 March 2021.

Study eligibility criteria

Population-based studies reporting the SARS-CoV-2 seroprevalence in the general population were included.

Participants

People of different age groups, occupations, educational levels, ethnic backgrounds and socio-economic status from the general population.

Interventions

There were no interventions.

Methods

We used the random-eﬀects meta-analyses and empirical Bayesian method to estimate the pooled seroprevalence and conducted subgroup and meta-regression analyses to explore potential sources of heterogeneity as well as the relationship between seroprevalence and socio-demographics.

Results

We identified 241 eligible studies involving 6.3 million individuals from 60 countries. The global pooled seroprevalence was 9.47% (95% CI 8.99-9.95%), although the heterogeneity among studies was significant (I² = 99.9%). We estimated that ∼738 million people had been infected with SARS-CoV-2 (as of December 2020). Highest and lowest seroprevalences were recorded in Central and Southern Asia (22.91%, 19.11-26.72%) and Eastern and South-eastern Asia (1.62%, 1.31-1.95%), respectively. Seroprevalence estimates were higher in males, persons aged 20-50 years, in minority ethnic groups living in countries or regions with low income and human development indices.

Conclusions

The present study indicates that the majority of the world's human population was still highly susceptible to SARS-CoV-2 infection in mid-2021, emphasizing the need for vaccine deployment to vulnerable groups of people, particularly in developing countries, and for the implementation of enhanced preventive measures until 'herd immunity' to SARS-CoV-2 has developed.

SUBMITTER: Rostami A

PROVIDER: S-EPMC8548624 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Update on SARS-CoV-2 seroprevalence: regional and worldwide.

Rostami Ali A Sepidarkish Mahdi M Fazlzadeh Aylar A Mokdad Ali H AH Sattarnezhad Aida A Esfandyari Sahar S Riahi Seyed Mohammad SM Mollalo Abolfazl A Dooki Mohammadreza Esmaeili ME Bayani Masomeh M Nazemipour Maryam M Mansournia Mohammad Ali MA Hotez Peter J PJ Gasser Robin B RB

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20210925 12

<h4>Background</h4>With limited vaccine supplies, an informed position on the status of SARS-CoV-2 infection in people can assist the prioritization of vaccine deployment.<h4>Objectives</h4>We performed a systematic review and meta-analysis to estimate the global and regional SARS-CoV-2 seroprevalences around the world.<h4>Data sources</h4>We systematically searched peer-reviewed databases (PubMed, Embase and Scopus), and preprint servers (medRxiv, bioRxiv and SSRN) for articles published betwee ...[more]

PMID: 34582980

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Project description:BackgroundThe higher hospitalisation rates of those aged 0-19 years (referred to herein as 'children') observed since the emergence of the immune-evasive SARS-CoV-2 Omicron variant and subvariants, along with the persisting vaccination disparities highlighted a need for in-depth knowledge of SARS-CoV-2 sero-epidemiology in children. Here, we conducted this systematic review to assess SARS-CoV-2 seroprevalence and determinants in children worldwide.MethodsIn this systematic review and meta-analysis study, we searched international and preprinted scientific databases from December 1, 2019 to July 10, 2022. Pooled seroprevalences were estimated according to World Health Organization (WHO) regions (at 95% confidence intervals, CIs) using random-effects meta-analyses. Associations with SARS-CoV-2 seroprevalence and sources of heterogeneity were investigated using sub-group and meta-regression analyses. The protocol used in this study has been registered in PROSPERO (CRD42022350833).FindingsWe included 247 studies involving 757,075 children from 70 countries. Seroprevalence estimates varied from 7.3% (5.8-9.1%) in the first wave of the COVID-19 pandemic to 37.6% (18.1-59.4%) in the fifth wave and 56.6% (52.8-60.5%) in the sixth wave. The highest seroprevalences in different pandemic waves were estimated for South-East Asia (17.9-81.8%) and African (17.2-66.1%) regions; while the lowest seroprevalence was estimated for the Western Pacific region (0.01-1.01%). Seroprevalence estimates were higher in children at older ages, in those living in underprivileged countries or regions, and in those of minority ethnic backgrounds.InterpretationOur findings indicate that, by the end of 2021 and before the Omicron wave, around 50-70% of children globally were still susceptible to SARS-CoV-2 infection, clearly emphasising the need for more effective vaccines and better vaccination coverage among children and adolescents, particularly in developing countries and minority ethnic groups.FundingNone.

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Dataset Information

Update on SARS-CoV-2 seroprevalence: regional and worldwide.

Background

Objectives

Data sources

Study eligibility criteria

Participants

Interventions

Methods

Results

Conclusions

Publications

Update on SARS-CoV-2 seroprevalence: regional and worldwide.

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