Immunomodulatory Proteins in Tick Saliva From a Structural Perspective.
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ABSTRACT:
SUBMITTER: Denisov SS
PROVIDER: S-EPMC8548845 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
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Immunomodulatory Proteins in Tick Saliva From a Structural Perspective.
Denisov Stepan S SS Dijkgraaf Ingrid I
Frontiers in cellular and infection microbiology 20211013
To feed successfully, ticks must bypass or suppress the host's defense mechanisms, particularly the immune system. To accomplish this, ticks secrete specialized immunomodulatory proteins into their saliva, just like many other blood-sucking parasites. However, the strategy of ticks is rather unique compared to their counterparts. Ticks' tendency for gene duplication has led to a diverse arsenal of dozens of closely related proteins from several classes to modulate the immune system's response. A ...[more]
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