Single-genome sequencing reveals within-host evolution of human malaria parasites.
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ABSTRACT:
SUBMITTER: Dia A
PROVIDER: S-EPMC8549078 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Single-genome sequencing reveals within-host evolution of human malaria parasites.
Dia Aliou A Jett Catherine C Trevino Simon G SG Chu Cindy S CS Sriprawat Kanlaya K Anderson Timothy J C TJC Nosten François F Cheeseman Ian H IH
Cell host & microbe 20210906 10
Population genomics of bulk malaria infections is unable to examine intrahost evolution; therefore, most work has focused on the role of recombination in generating genetic variation. We used single-cell sequencing protocol for low-parasitaemia infections to generate 406 near-complete single Plasmodium vivax genomes from 11 patients sampled during sequential febrile episodes. Parasite genomes contain hundreds of de novo mutations, showing strong signatures of selection, which are enriched in the ...[more]
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