Dataset Information

Perampanel as first add-on antiseizure medication: Italian consensus clinical practice statements.

ABSTRACT:

Background

When use of a single antiseizure medication (ASM) fails to induce seizure remission, add-on therapy is justified. Perampanel (PER) is approved in Europe as adjunctive therapy for focal, focal to bilateral tonic-clonic seizures and generalized tonic-clonic seizures. Aim of the study was to establish whether PER is suitable for first add-on use.

Methods

A Delphi methodology was adopted to assess consensus on a list of 39 statements produced by an Expert Board of 5 epileptologists. Using an iterative process, statements were finalized by a Delphi Panel of 84 Italian pediatric and adult neurologists. Each statement was rated anonymously to determine level of agreement on a 9-point Likert scale. Consensus was established as agreement by at least 80% of the panelists. The relevance of each statement was also assessed on a 3-point scale.

Results

Consensus was achieved for 37 statements. Characteristics of PER considered to justify its use as first add-on include evidence of a positive impact on quality of life based on long term retention data, efficacy, tolerability, and ease of use; no worsening of cognitive functions and sleep quality; a low potential for drug interactions; a unique mechanism of action. Potential unfavorable factors are the need for a relatively slow dose titration; the potential occurrence of behavioral adverse effects; lack of information on safety when used in pregnancy; limited access to plasma PER levels.

Conclusion

Perampanel has many features which justify its use as a first add-on. Choice of an ASM as first add-on should be tailored to individual characteristics.

SUBMITTER: Bonanni P

PROVIDER: S-EPMC8549193 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Perampanel as first add-on antiseizure medication: Italian consensus clinical practice statements.

Bonanni Paolo P Gambardella Antonio A Tinuper Paolo P Acone Benedetto B Perucca Emilio E Coppola Giangennaro G

BMC neurology 20211026 1

<h4>Background</h4>When use of a single antiseizure medication (ASM) fails to induce seizure remission, add-on therapy is justified. Perampanel (PER) is approved in Europe as adjunctive therapy for focal, focal to bilateral tonic-clonic seizures and generalized tonic-clonic seizures. Aim of the study was to establish whether PER is suitable for first add-on use.<h4>Methods</h4>A Delphi methodology was adopted to assess consensus on a list of 39 statements produced by an Expert Board of 5 epilept ...[more]

PMID: 34702211

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Dataset Information

Perampanel as first add-on antiseizure medication: Italian consensus clinical practice statements.

Background

Methods

Results

Conclusion

Publications

Perampanel as first add-on antiseizure medication: Italian consensus clinical practice statements.

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