Ontology highlight
ABSTRACT:
SUBMITTER: Zhou HQ
PROVIDER: S-EPMC8549799 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Chemical science 20210920 41
Catalytic asymmetric variants for functional group transformations based on carbon-carbon bond activation still remain elusive. Herein we present an unprecedented palladium-catalyzed (3 + 2) spiro-annulation merging C(sp<sup>2</sup>)-C(sp<sup>2</sup>) σ bond activation and click desymmetrization to form synthetically versatile and value-added oxaspiro products. The operationally straightforward and enantioselective palladium-catalyzed atom-economic annulation process exploits a TADDOL-derived bu ...[more]