Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study-a randomized clinical trial.

ABSTRACT:

Purpose

Hyperglycaemia is an adaptive response to stress commonly observed in critical illness. Its management remains debated in the intensive care unit (ICU). Individualising hyperglycaemia management, by targeting the patient's pre-admission usual glycaemia, could improve outcome.

Methods

In a multicentre, randomized, double-blind, parallel-group study, critically-ill adults were considered for inclusion. Patients underwent until ICU discharge either individualised glucose control by targeting the pre-admission usual glycaemia using the glycated haemoglobin A1c level at ICU admission (IC group), or conventional glucose control by maintaining glycaemia below 180 mg/dL (CC group). A non-commercial web application of a dynamic sliding-scale insulin protocol gave to nurses al

SUBMITTER: Bohe J 

PROVIDER: S-EPMC8550173 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature