Flexible Doppler ultrasound device for the monitoring of blood flow velocity
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ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC8550238 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Background and Aim: Newborns needing major surgical intervention are at risk of brain injury and impaired neurodevelopment later in life. Disturbance of cerebral perfusion might be an underlying factor. This study investigates the feasibility of serial transfontanellar ultrasound measurements of the pial arteries during neonatal surgery, and whether perioperative changes in cerebral perfusion can be observed and related to changes in the perioperative management. Methods: In this prospective, observational feasibility study, neonates with congenital diaphragmatic hernia and esophageal atresia scheduled for surgical treatment within the first 28 days of life were eligible for inclusion. We performed transfontanellar directional power Doppler and pulsed wave Doppler ultrasound during major high-risk non-cardiac neonatal surgery. Pial arteries were of interest for the measurements. Extracted Doppler ultrasound parameters were: peak systolic velocity, end diastolic velocity, the resistivity index and pulsatility index. Results: In 10 out of 14 patients it was possible to perform perioperative measurements; the others failed for logistic and technical reasons. In 6 out of 10 patients, it was feasible to perform serial intraoperative transfontanellar ultrasound measurements with directional power Doppler and pulsed wave Doppler of the same pial artery during neonatal surgery. Median peak systolic velocity was ranging between 5.7 and 7.0 cm s-1 and end diastolic velocity between 1.9 and 3.2 cm s-1. In patients with a vasoactive-inotropic score below 12 the trend of peak systolic velocity and end diastolic velocity corresponded with the mean arterial blood pressure trend. Conclusion: Perioperative transfontanellar ultrasound Doppler measurements of the pial arteries are feasible and provide new longitudinal data about perioperative cortical cerebral blood flow velocity. Trial Registration: https://www.trialregister.nl/trial/6972, identifier: NL6972.
| S-EPMC8019737 | biostudies-literature
Project description:Multiple lines of evidence suggest that cardiovascular co-morbidities hasten the onset of Alzheimer's disease (AD) or accelerate its course.To evaluate the utility of cerebral vascular physical function and/or condition parameters as potential systemic indicators of AD, transcranial Doppler (TCD) ultrasound was used to assess cerebral blood flow and vascular resistance of the 16 arterial segments comprising the circle of Willis and its major tributaries.Our study showed that decreased arterial mean flow velocity and increased pulsatility index are associated with a clinical diagnosis of presumptive AD. Cerebral blood flow impairment shown by these parameters reflects the global hemodynamic and structural consequences of a multifaceted disease process yielding diffuse congestive microvascular pathology, increased arterial rigidity, and decreased arterial compliance, combined with putative age-associated cardiovascular output declines.TCD evaluation offers direct physical confirmation of brain perfusion impairment and might ultimately provide a convenient and a noninvasive means to assess the efficacy of medical interventions on cerebral blood flow or reveal incipient AD. In the near term, TCD-based direct assessments of brain perfusion might offer the prospect of preventing or mitigating AD simply by revealing patients who would benefit from interventions to improve circulatory system function.
| S-EPMC3117072 | biostudies-literature
Project description:OBJECTIVE:Novel applications of transcranial Doppler (TCD) ultrasonography, such as the assessment of cerebral vessel narrowing/occlusion or the non-invasive estimation of intracranial pressure (ICP), require high-quality maximal flow velocity waveforms. However, due to the low signal-to-noise ratio of TCD spectrograms, measuring the maximal flow velocity is challenging. In this work, we propose a calibration-free algorithm for estimating maximal flow velocities from TCD spectrograms and present a pertaining beat-by-beat signal quality index. METHODS:Our algorithm performs multiple binary segmentations of the TCD spectrogram and then extracts the pertaining envelopes (maximal flow velocity waveforms) via an edge-following step that incorporates physiological constraints. The candidate maximal flow velocity waveform with the highest signal quality index is finally selected. RESULTS:We evaluated the algorithm on 32 TCD recordings from the middle cerebral and internal carotid arteries in 6 healthy and 12 neurocritical care patients. Compared to manual spectrogram tracings, we obtained a relative error of -1.5%, when considering the whole waveform, and a relative error of -3.3% for the peak systolic velocity. CONCLUSION:The feedback loop between the signal quality assessment and the binary segmentation yields a robust algorithm for maximal flow velocity estimation. Clinical Impact: The algorithm has already been used in our ICP estimation pipeline. By making the code and the data publicly available, we hope that the algorithm will be a useful building block for the development of novel TCD applications that require high-quality flow velocity waveforms.
| S-EPMC7398472 | biostudies-literature
Project description:Conventional color Doppler ultrasound imaging suffers from mutual frequency cancellation when applied to quantify axial blood flow velocities in the rodent brain where inverse flows exist within an ultrasound measurement voxel. Here, we report an improved color Doppler-based functional ultrasound imaging method (iCD-fUS) for axial blood flow velocity imaging of the rodent brain. By applying a directional filter and high frequency noise thresholding, iCD-fUS is able to accurately quantify blood flow velocities within the brain as validated with the ultrasound localization microscopy velocimetry method. We show that iCD-fUS is able to image and resolve the directional axial blood flow velocity throughout the entire coronal section of the brain at a temporal frame rate of up to 10 Hz with a spatial resolution of ~100 [Formula: see text]. We further applied iCD-fUS to image the axial blood flow velocity change in response to whisker stimulation in an awake mouse, showing its potential for studying brain activation. With these capabilities, iCD-fUS provides a powerful, quantitative tool for in vivo chronic research.
| S-EPMC8098776 | biostudies-literature
Project description:To evaluate the inter-device reproducibility of retrobulbar blood flow measurements obtained by two commercially available CDI (color Doppler imaging) devices.The right eyes of 10 healthy volunteers were investigated. Four examiners, namely two ophthalmologists and two radiologists, performed CDI examination of the ophthalmic artery, central retinal artery and temporal short posterior ciliary arteries using both CDI devices: ESAOTE MYLAB™ and SIEMENS ANTARES STELLAR PLUS™. The peak systolic velocity (PSV), the end-diastolic velocity (EDV) and the resulting resistivity index (RI) were averaged for 3 cardiac cycles. To evaluate the reproducibility between both device measurements, the Lin's concordance correlation coefficient (CCC) was used. CCC can be expressed as the product of Pearson's r (the measure of precision) and C_b (the measure of accuracy).Results show that the inter-device reproducibility for CDI measurements is not acceptable since a poor degree of overall concordance (0.15<CCC<0.37) was obtained: accuracy was high (C_b > 0.71) but overall precision low (0.18< Pearson's r <0.47). Ophthalmologists and radiologists obtained similar results.To evaluate the causal role of blood flow abnormalities in glaucoma, CDI analysis using different devices seems unreliable. CDI inter-device reproducibility seems unrelated to medical speciality of the examiners. However, to improve present results, the use of similar probes and standardized CDI instrument settings as well as a CDI images analysis by a single grader, might possibly improve the inter-device reproducibility when testing the retrobulbar blood flow velocity.
| S-EPMC4879017 | biostudies-other
Project description:Four-dimensional (4D) flow magnetic resonance imaging (MRI) allows three-dimensional velocity encoding to measure blood flow in a single scan, regardless of the intracranial artery direction. We compared blood flow velocity quantification by non-contrast 4D flow MRI and by transcranial Doppler ultrasound (TCD), the most widely used modality for measuring velocity. Twenty-two patients underwent both TCD and non-contrast 4D flow MRI. The mean time interval between TCD and non-contrast 4D flow MRI was 0.7 days. Subsegmental velocities were measured bilaterally in the middle cerebral and basilar arteries using TCD and non-contrast 4D flow MRI. Intracranial velocity measurements using TCD and non-contrast 4D flow MRI demonstrated a strong correlation in the bilateral M1, especially at the proximal segment (right r = 0.74, left r = 0.78; all p < 0.001). Mean velocities acquired with 4D flow MRI were approximately 8 to 10% lower than those acquired with TCD according to the location of M1. Intracranial arterial flow measurements estimated using non-contrast 4D flow MRI and TCD showed strong correlation. 4D flow MRI enables simultaneous assessment of vascular morphology and quantitative hemodynamic measurement, providing three-dimensional blood flow visualization. 4D flow MRI is a clinically useful sequence with a promising role in cerebrovascular disease.
| S-EPMC8774649 | biostudies-literature
Project description:BackgroundUltra-high field magnetic resonance imaging (MR) may be used to improve intracranial blood flow measurements. However, standard cardiac synchronization methods tend to fail at ultra-high field MR. Therefore, this study aims to investigate an alternative synchronization technique using Doppler ultrasound.MethodsHealthy subjects (n?=?9) were examined with 7T MR. Flow was measured in the M1-branch of the middle cerebral artery (MCA) and in the cerebral aqueduct (CA) using through-plane phase contrast (2D flow). Flow in the circle of Willis was measured with three-dimensional, three-directional phase contrast (4D flow). Scans were gated with Doppler ultrasound (DUS) and electrocardiogram (ECG), and pulse oximetry data (POX) was collected simultaneously. False negative and false positive trigger events were counted for ECG, DUS and POX, and quantitative flow measures were compared.ResultsThere were fewer false positive triggers for DUS compared to ECG (5.3?±?11 vs. 25?±?31, p?=?0.031), while no other measured parameters differed significantly. Net blood flow in M1 was similar between DUS and ECG for 2D flow (1.5?±?0.39 vs. 1.6?±?0.41, bias?±?1.96SD: -?0.021?±?0.36) and 4D flow (1.8?±?0.48 vs. 9?±?0.59, bias?±?1.96SD: -?0.086?±?0.57 ml). Net CSF flow per heart beat in the CA was also similar for DUS and ECG (3.6?±?2.1 vs. 3.0?±?5.8, bias?±?1.96SD: 0.61?±?13.6 ?l).ConclusionGating with DUS produced fewer false trigger events than using ECG, with similar quantitative flow values. DUS gating is a promising technique for cardiac synchronization at 7T.
| S-EPMC7724705 | biostudies-literature
Project description:We demonstrate a new method to recover 4D blood flow over the entire ventricle from partial blood velocity measurements using multiple 3D+t colour Doppler images and ventricular wall motion estimated using 3D+t BMode images. We apply our approach to realistic simulated data to ascertain the ability of the method to deal with incomplete data, as typically happens in clinical practice. Experiments using synthetic data show that the use of wall motion improves velocity reconstruction, shows more accurate flow patterns and improves mean accuracy particularly when coverage of the ventricle is poor. The method was applied to patient data from 6 congenital cases, producing results consistent with the simulations. The use of wall motion produced more plausible flow patterns and reduced the reconstruction error in all patients.
| S-EPMC7115944 | biostudies-literature
Project description:Cerebral autoregulation (CA) is the mechanism by which constant cerebral blood flow is maintained despite changes in cerebral perfusion pressure. CA can be evaluated by dynamic monitoring of cerebral blood flow velocity (CBFV) with transcranial Doppler sonography (TCD). The present study aimed to explore CA in chronic anxiety.Subjects with Hamilton anxiety scale scores ≥14 were enrolled and the dynamic changes of CBFV in response to an orthostatic challenge were investigated using TCD.In both the anxious and the healthy subjects, the mean CBFV was significantly lower in the upright position than when supine. However, the CBFV changes from supine to upright differed between the anxious and the healthy groups. Anxious subjects showed more pronounced decreases in CBFV with abrupt standing.Our results indicate that cerebrovascular modulation is compromised in chronic anxiety; anxious subjects have some insufficiency in maintaining cerebral perfusion after postural change. Given the fact that anxiety and impaired CA are associated with cardiovascular disease, early ascertainment of compromised cerebrovascular modulation using TCD might suggest interventional therapies in the anxious population, and improve the primary prevention of cardiovascular disease.
| S-EPMC5561819 | biostudies-other
Project description:Novel flexible thin mm-sized resistance-typed sensor film (MRSF) fabricated using ink-jet printing technology (IPT) was developed in this study to monitor water flow rate in pipelines in real time in situ mode. The mechanism of MRSF is that the mm-sized interdigitated electrodes made by printing silver nanoparticles on an elastic polyimide film bend under different flow rates, leading to variation of the resistance of the sensor at different degrees of curvature. Continuous flow tests showed that MRSF possessed a high accuracy (0.2?m/s) and excellent sensitivity (0.1447/ms-1). A model of sensor resistance and flow velocity was established to unfold the correlation between the fundamentals of fluid mechanics and the mechanic flexibility of sensor materials. An analytical model yielded a high coefficient of determination (R2?>?0.93) for the relationship between the resistance increment of the MRSF and the square of the flow velocity at the velocity range of 0.25-2?m/s. Furthermore, a temperature-correction model was developed to quantify the effect of water temperature on the sensor resistance readings. MRSF exhibited a low temperature coefficient of resistance (TCR, 0.001) at the water temperature range of 20-60?°C. Computational fluid dynamics (CFD) simulations using the finite element method were conducted and confirmed both the underlying load assumptions and the deformation characteristics of the sensor film under various flow and material conditions. High-resolution monitoring of water flow rate using MRSF technology was expected to save at least 50% energy consumption for a given unit, especially under flow fluctuation. MRSF possesses a great potential to perform real-time in situ monitoring at high accuracy with ultralow cost, thus enabling the feedback control at high spatiotemporal resolution to reduce the overall energy consumption in water and wastewater systems.
| S-EPMC6614588 | biostudies-literature