Structural and functional analysis of somatic coding and UTR indels in breast and lung cancer genomes.

ABSTRACT: Insertions and deletions (Indels) represent one of the major variation types in the human genome and have been implicated in diseases including cancer. To study the features of somatic indels in different cancer genomes, we investigated the indels from two large samples of cancer types: invasive breast carcinoma (BRCA) and lung adenocarcinoma (LUAD). Besides mapping somatic indels in both coding and untranslated regions (UTRs) from the cancer whole exome sequences, we investigated the overlap between these indels and transcription factor binding sites (TFBSs), the key elements for regulation of gene expression that have been found in both coding and non-coding sequences. Compared to the germline indels in healthy genomes, somatic indels contain more coding indels with higher than expected

SUBMITTER: Chen J 

PROVIDER: S-EPMC8551294 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature