Metabolic Acidosis and Cardiovascular Disease in CKD.

ABSTRACT:

Rationale & objective

Metabolic acidosis related to chronic kidney disease (CKD) is associated with an accelerated decline in glomerular filtration rate (GFR) and the development of end-stage kidney disease. Whether metabolic acidosis is associated with cardiovascular (CV) events in patients with CKD is unclear.

Study design

Retrospective cohort study.

Setting & participants

The Optum De-identified Electronic Health Records Dataset, 2007-2017, was used to generate a cohort of patients with non-dialysis-dependent CKD who had at least 3 estimated GFR < 60 mL/min/1.73 m². Patients with metabolic acidosis (serum bicarbonate 12 to <22 mEq/L) or normal serum bicarbonate (22‒29 mEq/L) at baseline were identified by 2 consecutive measurements 28‒365 days apart.

SUBMITTER: Collister D 

PROVIDER: S-EPMC8551483 | biostudies-literature | 2021 Sep-Oct

REPOSITORIES: biostudies-literature