Vitamin D Receptor Is a Sepsis-Susceptibility Gene in Chinese Children
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ABSTRACT: Background
We designed an association study among 267 cases of children with sepsis and 283 healthy controls, by genotyping 9 variants in the VDR gene. Material/Methods
This was a hospital-based, case-control, genetic association study. In addition to 3 genetic modes of inheritance, haplotype and interaction analyses were employed to examine the prediction of VDR gene for pediatric sepsis. Effect-size estimates are expressed as odds ratio (OR) and 95% confidence interval (CI). Results
Two variants in the VDR gene, rs2107301 and rs2189480, were found to play a leading role in susceptibility to sepsis in children. The mutant homozygotes of rs2107301 (CC) and rs2189480 (CC) were associated with a reduced risk of sepsis compared with the corresponding wild homozygotes (OR: 0.44 and 0.43, 95% CI: 0.21–0.92 and 0.23–0.81, p: 0.03 and 0.009, respectively). The mutations of rs2107301-C and rs2189480-C alleles were associated with reduced sepsis risk. Haplotype C-C-C-C-C-T-C-A-G in the VDR gene was significantly associated with a 0.59-fold decreased risk of sepsis (95% CI: 0.12–0.76, p: 0.02). In the haplotype–phenotype analysis, significant association was noted for high-density lipoprotein, even after simulation correction (psim <0.05). Conclusions
Taken together, our findings indicate that the VDR gene may be a sepsis-susceptibility gene in Chinese Han children.
SUBMITTER: He D
PROVIDER: S-EPMC8552509 | biostudies-literature |
REPOSITORIES: biostudies-literature
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