Characterization of hormone-producing cell types in the teleost pituitary gland using single-cell RNA-seq.

ABSTRACT: The pituitary is the vertebrate endocrine gland responsible for the production and secretion of several essential peptide hormones. These, in turn, control many aspects of an animal's physiology and development, including growth, reproduction, homeostasis, metabolism, and stress responses. In teleost fish, each hormone is presumably produced by a specific cell type. However, key details on the regulation of, and communication between these cell types remain to be resolved. We have therefore used single-cell sequencing to generate gene expression profiles for 2592 and 3804 individual cells from the pituitaries of female and male adult medaka (Oryzias latipes), respectively. Based on expression profile clustering, we define 15 and 16 distinct cell types in the female and male pituitary, resp

SUBMITTER: Siddique K 

PROVIDER: S-EPMC8553774 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature