Ontology highlight
ABSTRACT:
SUBMITTER: Makhoul I
PROVIDER: S-EPMC8555684 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Makhoul Issam I Ibrahim Saddam Mohammed SM Abu-Rmaileh Muhammad M Jousheghany Fariba F Siegel Eric R ER Rogers Lora J LJ Lee John J JJ Pina-Oviedo Sergio S Post Ginell R GR Beck J Thaddeus JT Kieber-Emmons Thomas T Monzavi-Karbassi Behjatolah B
Oncotarget 20211026 22
Breast cancer patients diagnosed with HR+/HER2- tumors face a persistent risk of distant recurrence long after completion of their treatment. Strategies to induce anti-tumor immune responses could complement standard-of-care therapies for these patients. The current study was performed to examine the feasibility, safety and immunogenicity of adding P10s-PADRE to standard-of-care chemotherapy in HR+/HER2- early-stage breast cancer patients. Twenty-five subjects were treated in a single-arm Phase ...[more]