Redistribution of brain glucose metabolism in people with HIV after antiretroviral therapy initiation.

ABSTRACT:

Objective

We evaluated brain glucose metabolism in people living with HIV (PWH) with [18F]-Fluoro-Deoxyglucose (FDG) PET/computed tomography (CT) before and after antiretroviral therapy (ART) initiation.

Design

We conducted a longitudinal study wherein ART-naive late-presenting untreated PWH with CD4+ cell counts less than 100 cells/μl were prospectively assessed for FDG uptake at baseline and at 4-8 weeks (n = 22) and 19-26 months (n = 11) following ART initiation.

Methods

Relative uptake in the subcortical regions (caudate, putamen and thalamus) and cortical regions (frontal, parietal, temporal and occipital cortices) were compared across time and correlated with biomarkers of disease activity and inflammation, in addition to being compared with a group of uninfecte

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8556661 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature