Improving CoQ₁₀ productivity by strengthening glucose transmembrane of Rhodobacter sphaeroides.

ABSTRACT:

Background

Several Rhodobacter sphaeroides have been widely applied in commercial CoQ₁₀ production, but they have poor glucose use. Strategies for enhancing glucose use have been widely exploited in R. sphaeroides. Nevertheless, little research has focused on the role of glucose transmembrane in the improvement of production.

Results

There are two potential glucose transmembrane pathways in R. sphaeroides ATCC 17023: the fructose specific-phosphotransferase system (PTS^Fru, fruAB) and non-PTS that relied on glucokinase (glk). fruAB mutation revealed two effects on bacterial growth: inhibition at the early cultivation phase (12-24 h) and promotion since 36 h. Glucose metabolism showed a corresponding change in characteristic vs. the growth. For ΔfruAΔfruB

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8557541 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature