Ontology highlight
ABSTRACT:
SUBMITTER: Farrelly O
PROVIDER: S-EPMC8559309 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Farrelly Olivia O Suzuki-Horiuchi Yoko Y Brewster Megan M Kuri Paola P Huang Sixia S Rice Gabriella G Bae Hyunjin H Xu Jianming J Dentchev Tzvete T Lee Vivian V Rompolas Panteleimon P
Cell stem cell 20210512 7
The functional heterogeneity of resident stem cells that support adult organs is incompletely understood. Here, we directly visualize the corneal limbus in the eyes of live mice and identify discrete stem cell niche compartments. By recording the life cycle of individual stem cells and their progeny, we directly analyze their fates and show that their location within the tissue can predict their differentiation status. Stem cells in the inner limbus undergo mostly symmetric divisions and are req ...[more]