Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma.
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ABSTRACT:
SUBMITTER: Du W
PROVIDER: S-EPMC8559338 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
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Lysosomal Zn<sup>2+</sup> release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma.
Du Wanlu W Gu Mingxue M Hu Meiqin M Pinchi Prateeksunder P Chen Wei W Ryan Michael M Nold Timothy T Bannaga Ahmed A Xu Haoxing H
Cell reports 20211001 3
During tumor progression, lysosome function is often maladaptively upregulated to match the high energy demand required for cancer cell hyper-proliferation and invasion. Here, we report that mucolipin TRP channel 1 (TRPML1), a lysosomal Ca<sup>2+</sup> and Zn<sup>2+</sup> release channel that regulates multiple aspects of lysosome function, is dramatically upregulated in metastatic melanoma cells compared with normal cells. TRPML-specific synthetic agonists (ML-SAs) are sufficient to induce rapi ...[more]
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