The impact of dopaminergic treatment over cognitive networks in Parkinson's disease: Stemming the tide?

ABSTRACT: Dopamine-replacing therapies are an effective treatment for the motor aspects of Parkinson's disease. However, its precise effect over the cognitive resting-state networks is not clear; whether dopaminergic treatment normalizes their functional connectivity-as in other networks- and the links with cognitive decline are presently unknown. We recruited 35 nondemented PD patients and 16 age-matched controls. Clinical and neuropsychological assessments were performed at baseline, and conversion to dementia was assessed in a 10 year follow-up. Structural and functional brain imaging were acquired in both the ON and practical OFF conditions. We assessed functional connectivity in both medication states compared to healthy controls, connectivity differences within participants related to the ON/O

SUBMITTER: Aracil-Bolanos I 

PROVIDER: S-EPMC8559512 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature