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Phytochemical-Based Nanocomposites for the Treatment of Bacterial Biofilms.

ABSTRACT: Biofilm infections are responsible for at least 65% of human bacterial infections. These biofilms are refractory to conventional antibiotics, leading to chronic infections and nonhealing wounds. Plant-derived antibiotics (phytochemicals) are promising alternative antimicrobial treatments featuring antimicrobial properties. However, their poor solubility in aqueous media limits their application in treating biofilm infections. Phytochemicals were incorporated into cross-linked polymer nanocomposite "sponges" for the treatment of bacterial biofilms. The results indicated encapsulating low log P phytochemicals effectively eliminated biofilms while demonstrating low cytotoxicity against mammalian fibroblast cells.

SUBMITTER: Li CH

PROVIDER: S-EPMC8559558 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Phytochemical-Based Nanocomposites for the Treatment of Bacterial Biofilms.

Li Cheng-Hsuan CH Chen Xinhong X Landis Ryan F RF Geng Yingying Y Makabenta Jessa Marie JM Lemnios William W Gupta Akash A Rotello Vincent M VM

ACS infectious diseases 20190710 9

Biofilm infections are responsible for at least 65% of human bacterial infections. These biofilms are refractory to conventional antibiotics, leading to chronic infections and nonhealing wounds. Plant-derived antibiotics (phytochemicals) are promising alternative antimicrobial treatments featuring antimicrobial properties. However, their poor solubility in aqueous media limits their application in treating biofilm infections. Phytochemicals were incorporated into cross-linked polymer nanocomposi ...[more]

PMID: 31251554

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