Characterization and prognostic value of LXR splice variants in triple-negative breast cancer.
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ABSTRACT:
SUBMITTER: Lianto P
PROVIDER: S-EPMC8560626 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Characterization and prognostic value of LXR splice variants in triple-negative breast cancer.
Lianto Priscilia P Hutchinson Samantha A SA Moore J Bernadette JB Hughes Thomas A TA Thorne James L JL
iScience 20211002 10
Activity of liver x receptor (LXR), the homeostatic regulator of cholesterol metabolism, is elevated in triple-negative breast cancer (BCa) relative to other BCa subtypes, driving drug resistance and metastatic gene signatures. The loci encoding LXRα and LXRβ produce multiple alternatively spliced proteins, but the true range of variants and their relevance to cancer remain poorly defined. Here, we report seven LXR splice variants, three of which have not previously been reported and five that w ...[more]
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