Ontology highlight
ABSTRACT:
SUBMITTER: Svoronos AA
PROVIDER: S-EPMC8560630 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Svoronos Alexander A AA Campbell Stuart G SG Engelman Donald M DM
iScience 20211002 10
Paradoxically, many microRNAs appear to exhibit entirely opposite functions when placed in different contexts. For example, miR-125b has been shown to be pro-apoptotic in some studies, but anti-apoptotic in others. To investigate this phenomenon, we combine computational modeling with experimental approaches to examine how the function of miR-125b in apoptosis varies with respect to the expression levels of its pro-apoptotic and anti-apoptotic targets. In doing so, we elucidate a general trend t ...[more]