Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons.

ABSTRACT: Proper regulation of neuronal morphological changes is essential for neuronal migration, maturation, synapse formation, and high-order function. Many cytoplasmic proteins involved in the regulation of neuronal microtubules and the actin cytoskeleton have been identified. In addition, some nuclear proteins have alternative functions in neurons. While cell cycle-related proteins basically control the progression of the cell cycle in the nucleus, some of them have an extra-cell cycle-regulatory function (EXCERF), such as regulating cytoskeletal organization, after exit from the cell cycle. Our expression analyses showed that not only cell cycle regulators, including cyclin A1, cyclin D2, Cdk4/6, p21^cip1, p27^kip1, Ink4 family, and RAD21, but also DNA repair proteins, incl

SUBMITTER: Akagawa R 

PROVIDER: S-EPMC8564117 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature