Disrupted Brain Connectivity Networks in Aphasia Revealed by Resting-State fMRI.

ABSTRACT: Aphasia is characterized by the disability of spontaneous conversation, listening, understanding, retelling, naming, reading, or writing. However, the neural mechanisms of language damage after stroke are still under discussion. This study aimed to investigate the global and nodal characterization of the functional networks in patients with aphasic stroke based on resting-state functional MRI (fMRI). Twenty-four right-handed patients with aphasia after stroke and 19 healthy controls (HC) underwent a 3-TfMRI scan. A whole-brain large-scale functional connectivity network was then constructed based on Power's atlas of 264 functional regions of interest, and the global and nodal topological properties of these networks were analyzed using graph theory approaches. The results showed that patie

SUBMITTER: Chen X 

PROVIDER: S-EPMC8565294 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature