Non-canonical LexA proteins regulate the SOS response in the Bacteroidetes.

ABSTRACT: Lesions to DNA compromise chromosome integrity, posing a direct threat to cell survival. The bacterial SOS response is a widespread transcriptional regulatory mechanism to address DNA damage. This response is coordinated by the LexA transcriptional repressor, which controls genes involved in DNA repair, mutagenesis and cell-cycle control. To date, the SOS response has been characterized in most major bacterial groups, with the notable exception of the Bacteroidetes. No LexA homologs had been identified in this large, diverse and ecologically important phylum, suggesting that it lacked an inducible mechanism to address DNA damage. Here, we report the identification of a novel family of transcriptional repressors in the Bacteroidetes that orchestrate a canonical response to DNA damage in thi

SUBMITTER: Sanchez-Osuna M 

PROVIDER: S-EPMC8565304 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature