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¹⁵N-Azides as practical and effective tags for developing long-lived hyperpolarized agents.

ABSTRACT: Azide moieties, unique linear species containing three nitrogen atoms, represent an attractive class of molecular tag for hyperpolarized magnetic resonance imaging (HP-MRI). Here we demonstrate (¹⁵N)₃-azide-containing molecules exhibit long-lasting hyperpolarization lifetimes up to 9.8 min at 1 T with remarkably high polarization levels up to 11.6% in water, thus establishing (¹⁵N)₃-azide as a powerful spin storage for hyperpolarization. A single (¹⁵N)-labeled azide has also been examined as an effective alternative tag with long-lived hyperpolarization. A variety of biologically important molecules are studied in this work, including choline, glucose, amino acid, and drug derivatives, demonstrating great potential of ¹⁵N-labeled azides as universal hyperpolarized tags for nuclear magnetic resonance imaging applications.

SUBMITTER: Bae J

PROVIDER: S-EPMC8565375 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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15N-Azides as practical and effective tags for developing long-lived hyperpolarized agents.

Bae Junu J Zhang Guannan G Park Hyejin H Warren Warren S WS Wang Qiu Q

Chemical science 20211012 42

Azide moieties, unique linear species containing three nitrogen atoms, represent an attractive class of molecular tag for hyperpolarized magnetic resonance imaging (HP-MRI). Here we demonstrate (15N)3-azide-containing molecules exhibit long-lasting hyperpolarization lifetimes up to 9.8 min at 1 T with remarkably high polarization levels up to 11.6% in water, thus establishing (15N)3-azide as a powerful spin storage for hyperpolarization. A single (<sup ...[more]

PMID: 34760217

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