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Diabetes coexistent with Charcot-Marie-Tooth disease presenting as a recurrent foot ulcer misdiagnosed as diabetic foot: A case report.

ABSTRACT: Both diabetes mellitus and Charcot-Marie-Tooth disease (CMT) can lead to severe peripheral neuropathy. The differential diagnosis of peripheral neuropathy is difficult due to the similar clinical features. There are still some clues, such as unusual muscle atrophy, unmatched severity of peripheral neurogenic damage with nephropathy or retinopathy, which could alert clinicians to make differential diagnosis. Although diabetes mellitus is rarely concurrent with CMT, it will exacerbate clinical disorders in patients with CMT. To date, there is no specific medicine for CMT treatment. Offloading devices and desirable comprehensive management of diabetes mellitus might be beneficial to avoid plantar ulcer recurrence and anti-progression of CMT.

SUBMITTER: Yan Z

PROVIDER: S-EPMC8565404 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Diabetes coexistent with Charcot-Marie-Tooth disease presenting as a recurrent foot ulcer misdiagnosed as diabetic foot: A case report.

Yan Zhe Z Chen Dawei D Yao Li L Wang Chun C Ran Xing-Wu XW

Journal of diabetes investigation 20210606 11

Both diabetes mellitus and Charcot-Marie-Tooth disease (CMT) can lead to severe peripheral neuropathy. The differential diagnosis of peripheral neuropathy is difficult due to the similar clinical features. There are still some clues, such as unusual muscle atrophy, unmatched severity of peripheral neurogenic damage with nephropathy or retinopathy, which could alert clinicians to make differential diagnosis. Although diabetes mellitus is rarely concurrent with CMT, it will exacerbate clinical dis ...[more]

PMID: 33991180

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2013-05-01 | E-GEOD-40610 | biostudies-arrayexpress

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Project description:Genetics of Charcot-Marie-Tooth Disease

| PRJNA382008 | ENA

SURF1 deficiency causes demyelinating Charcot-Marie-Tooth disease.

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