Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways.

ABSTRACT: Polyphenols constitute an important group of natural products that are traditionally associated with a wide range of bioactivities. These are usually found in low concentrations in natural products and are now available in nutraceuticals or dietary supplements. A group of polyphenols that include apigenin, quercetin, curcumin, resveratrol, EGCG, and kaempferol have been shown to regulate signaling pathways that are central for cancer development, progression, and metastasis. Here, we describe novel mechanistic insights on the effect of this group of polyphenols on key elements of the signaling pathways impacting cancer. We describe the protein modifications induced by these polyphenols and their effect on the central elements of several signaling pathways including PI3K, Akt, mTOR, RAS, an

SUBMITTER: Chairez-Ramirez MH 

PROVIDER: S-EPMC8565650 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature