Determinants of late detection and advanced-stage diagnosis of breast cancer in Nigeria.
Ontology highlight
ABSTRACT: Objective
To describe the risk factors for late detection and advanced-stage diagnosis among patients who detected their BC early.Method
Using secondary data, we analyzed the impact of socio-demographic factors, premorbid experience, BC knowledge, and health-seeking pattern on the risk of late detection and advanced-stage diagnosis after early BC detection. Test of statistical significance in SPSS and EasyR was set at 5% using Sign-test, chi-square tests (of independence and goodness of fit), odds ratio, or risk ratio as appropriate.Result
Most socio-demographic factors did not affect detection size or risk of disease progression in the 405 records analyzed. High BC knowledge, p-value = 0.001, and practicing breast self-examination (BSE) increased early detection, p-value = 0.04, with a higher probability (OR 1.6 (95% CI 1.1-2.5) of detecting <2cm lesions. Visiting alternative care (RR 1.5(95% CI 1.2-1.9), low BC knowledge (RR 1.3(95% CI 1.1-1.9), and registering concerns for hospital care increased the risk of advanced-stage diagnosis after early detection (64% (95% CI 55-72)). Adhering to the monthly BSE schedule reduced the risk of advanced-stage diagnosis by -25% (95% CI -49, -1.1) in the presence of socioeconomic barriers.Conclusion
Strategies to increase BC knowledge and BSE may help BC downstaging, especially among women with common barriers to early diagnosis.
SUBMITTER: Agodirin O
PROVIDER: S-EPMC8565753 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Determinants of late detection and advanced-stage diagnosis of breast cancer in Nigeria.
Agodirin Olayide O Olatoke Samuel S Rahman Ganiyu G Kolawole Oladapo O Oguntola Saliu S Olasehinde Olalekan O Ayandipo Omobolaji O Olaogun Julius J Katung Aba A Etonyeaku Amarachukwu A Habeeb Olufemi O Adeyeye Ademola A Agboola John J Akande Halimat H Akanbi Olusola O Fatudimu Oluwafemi O Ajiboye Anthony A
PloS one 20211103 11
<h4>Objective</h4>To describe the risk factors for late detection and advanced-stage diagnosis among patients who detected their BC early.<h4>Method</h4>Using secondary data, we analyzed the impact of socio-demographic factors, premorbid experience, BC knowledge, and health-seeking pattern on the risk of late detection and advanced-stage diagnosis after early BC detection. Test of statistical significance in SPSS and EasyR was set at 5% using Sign-test, chi-square tests (of independence and good ...[more]
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Project description:ImportanceCardiovascular disease (CVD) and cancer are the leading causes of mortality in the US. Large-scale population-based and mechanistic studies support a direct effect of CVD on accelerated tumor growth and spread, specifically in breast cancer.ObjectiveTo assess whether individuals presenting with advanced breast cancers are more likely to have prevalent CVD compared with those with early-stage breast cancers at the time of diagnosis.Design, setting, and participantsThis population-based case-control study used data from the Surveillance, Epidemiology, and End Results-Medicare linked databases from 2009 to 2020. The analysis was completed from May 2023 to August 2024. Participants were female patients aged at least 66 years diagnosed with invasive breast cancer. Cases were matched with controls by breast cancer stage at diagnosis and propensity scores using factors known to be associated with delayed cancer diagnosis.ExposurePrevalent CVD prior to breast cancer diagnosis.Main outcomes and measuresThe outcome of interest was the odds of locally advanced (T3-4 or N+) or metastatic (M+) breast cancer status at diagnosis.ResultsThe full analytic cohort included 19 292 matched individuals, with median (IQR) age 73 (70-79) years, of whom 1676 (8.7%) were Black and 16 681 (86.5%) were White; 9478 individuals (49.1%) had prevalent CVD. Propensity score-matched, multivariable-adjusted models found that individuals with locally advanced or metastatic breast cancer at diagnosis had statistically significantly increased odds of prevalent CVD (odds ratio [OR], 1.10; 95% CI, 1.03-1.17; P = .007). This association was observed among hormone receptor-positive (OR, 1.11; 95% CI, 1.03-1.19; P = .006) but not hormone receptor-negative (OR, 1.02; 95% CI, 0.86-1.21; P = .83) breast cancer. ORs were directionally consistent when separately examining locally advanced (OR, 1.09; 95% CI, 1.02-1.17; P = .02) and metastatic (OR, 1.20; 95% CI, 0.94-1.54; P = .15) disease, among all receptor subtypes.Conclusions and relevanceThis case-control study found that individuals with more advanced breast cancer at diagnosis were more likely to have prevalent CVD. This finding may be specific to hormone receptor-positive and ERBB2-negative (formerly HER2) disease. Future studies are needed to confirm these findings and investigate interventions to improve patient outcomes, including personalized cancer screening.
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