Ontology highlight
ABSTRACT:
SUBMITTER: Matsuoka Y
PROVIDER: S-EPMC8566498 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Matsuoka Yuta Y Takahashi Masatomo M Sugiura Yuki Y Izumi Yoshihiro Y Nishiyama Kazuhiro K Nishida Motohiro M Suematsu Makoto M Bamba Takeshi T Yamada Ken-Ichi KI
Nature communications 20211103 1
Although oxidized phosphatidylcholines (oxPCs) play critical roles in numerous pathological events, the type and production sites of endogenous oxPCs remain unknown because of the lack of structural information and dedicated analytical methods. Herein, a library of 465 oxPCs is constructed using high-resolution mass spectrometry-based non-targeted analytical methods and employed to detect 70 oxPCs in mice with acetaminophen-induced acute liver failure. We show that doubly oxygenated polyunsatura ...[more]