Preliminary investigation of two promoter region polymorphisms of the TNFA gene in patients with recurrent depressive disorder.

ABSTRACT: Immune system dysregulation plays a role in the pathogenesis of complex human diseases, including psychiatric disorders. In addition, elevated levels of pro-inflammatory cytokines, including tumor necrosis factor α (TNF-α) may be conditioned by the presence of specific polymorphic variants. The present case-controlled preliminary study evaluated the prevalence of TNFA gene single nucleotide polymorphisms (SNPs) G-308A (rs1800629) and T-1031C (rs1799964) in 83 Polish patients with depression by restriction fragment length polymorphism analysis. The results were compared with the frequencies of genotypes in a geographically- and ethnically-matched group of individuals without depression. No statistically significant difference in genotype/allele frequency was observed for either SNP b

SUBMITTER: Jelen A 

PROVIDER: S-EPMC8567462 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature