Acute exposure to traffic-related air pollution alters antioxidant status in healthy adults.

ABSTRACT:

Background

Exposure to traffic-related air pollution is associated with an increased risk of cardiovascular and respiratory disease. Evidence suggests that inhaled pollutants precipitate these effects via multiple pathways involving oxidative stress.

Objective

Postulating that a decrease in circulating antioxidant levels reflect an oxidative response, we investigated the effect of inhaled diesel exhaust (DE) on the ratio of reduced to oxidized glutathione (GSH/GSSG) in healthy adults, and whether pre-exposure antioxidant supplementation blunted this response. We also examined exposure-related changes in antioxidant/stress response leukocyte gene expression (GCLc, HMOX-1, IL-6, TGFβ) and plasma IL-6 levels.

Methods

Nineteen nonsmoking adults participated in a double-bl

SUBMITTER: Cosselman KE 

PROVIDER: S-EPMC8568481 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature