Unknown

Dataset Information

0

Korean Red Ginseng exerts anti-inflammatory and autophagy-promoting activities in aged mice


ABSTRACT:

Background

Korean Red Ginseng (KRG) is a traditional herb that has several beneficial properties including anti-aging, anti-inflammatory, and autophagy regulatory effects. However, the mechanisms of these effects are not well understood. In this report, the underlying mechanisms of anti-inflammatory and autophagy-promoting effects were investigated in aged mice treated with KRG-water extract (WE) over a long period.

Methods

The mechanisms of anti-inflammatory and autophagy-promoting activities of KRG-WE were evaluated in kidney, lung, liver, stomach, and colon of aged mice using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), quantitative RT-PCR (qRT-PCR), and western blot analysis.

Results

KRG-WE significantly suppressed the mRNA expression levels of inflammation-related genes such as interleukin (IL)-1β, IL-8, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein-1 (MCP-1), and IL-6 in kidney, lung, liver, stomach, and colon of the aged mice. Furthermore, KRG-WE downregulated the expression of transcription factors and their protein levels associated with inflammation in lung and kidney of aged mice. KRG-WE also increased the expression of autophagy-related genes and their protein levels in colon, liver, and stomach.

Conclusion

The results suggest that KRG can suppress inflammatory responses and recover autophagy activity in aged mice. Graphical abstract Image 1

SUBMITTER: Kim J 

PROVIDER: S-EPMC8569327 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5005313 | biostudies-literature
| S-EPMC10310874 | biostudies-literature
| S-EPMC7412055 | biostudies-literature
| S-EPMC5878047 | biostudies-literature
2022-07-13 | GSE154388 | GEO
| S-EPMC6990786 | biostudies-literature
2009-08-09 | GSE12656 | GEO
| S-EPMC7655494 | biostudies-literature
| S-EPMC7825445 | biostudies-literature
| S-EPMC7587592 | biostudies-literature