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α-Fe₂O₃@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O₂ and imaging-guidance.

ABSTRACT: Sonodynamic therapy (SDT), presenting spatial and temporal control of ROS generation triggered by ultrasound field, has attracted considerable attention in tumor treatment. However, its therapeutic efficacy is severely hindered by the intrinsic hypoxia of solid tumor and the lack of smart design in material band structure. Here in study, fine α-Fe₂O₃ nanoparticles armored with Pt nanocrystals (α-Fe₂O₃@Pt) was investigated as an alternative SDT agent with ingenious bandgap and structural design. The Schottky barrier, due to its unique heterostructure, suppresses the recombination of sono-induced electrons and holes, enabling superior ROS generation. More importantly, the composite nanoparticles may effectively trigger a reoxygenation phenomenon to supply sufficient content of oxygen, favoring the ROS induction under the hypoxic condition and its extra role played for ultrasound imaging. In consequence, α-Fe₂O₃@Pt appears to enable effective tumor inhibition with imaging guidance, both in vitro and in vivo. This study has therefore demonstrated a highly potential platform for ultrasound-driven tumor theranostic, which may spark a series of further explorations in therapeutic systems with more rational material design.

SUBMITTER: Zhang T

PROVIDER: S-EPMC8569996 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance.

Zhang Tian T Zheng Qiang Q Fu Yike Y Xie Congkun C Fan Gonglin G Wang Yifan Y Wu Yongjun Y Cai Xiujun X Han Gaorong G Li Xiang X

Journal of nanobiotechnology 20211104 1

Sonodynamic therapy (SDT), presenting spatial and temporal control of ROS generation triggered by ultrasound field, has attracted considerable attention in tumor treatment. However, its therapeutic efficacy is severely hindered by the intrinsic hypoxia of solid tumor and the lack of smart design in material band structure. Here in study, fine α-Fe2O3 nanoparticles armored with Pt nanocrystals (α-Fe2O3@Pt) was investigated as an alternative SDT agent wi ...[more]

PMID: 34736483

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Project description:This work thoroughly investigates chemical solvent-particles interactions during the formation of composite particles by pulsed laser melting of α-Fe2O3. Two solvents, with different dielectric constants, such as ethyl acetate (εr = 6) and ethanol (εr = 24.6), were examined in terms of their effect on the morphology, size, and phase composition of iron oxide composites. We calculated the laser fluence curves using the heating-melting-evaporation approach to identify the critical particle size that undergoes the phase changes first. We assessed the temperature of the particles irradiated with 390 mJ/pulse.cm2 in both solvents, including the heat dissipation between the particles and the liquid. The phase diagram of the Fe-O-C-H system was calculated to determine the temperature-pressure relationship of the system in equilibrium. We also employed an in situ GC-MS analysis to identify the volatile products during irradiation. Based on our experimental results, we concluded that the final diameter of the composites increases from 400 to 600 nm, along with the decreasing dielectric constant of the solvent, which is related to the different polarization of the organic liquid and the degree of particle agglomeration. The reduction of hematite in ethanol proceeded much faster, ending up with Fe/FeCx, while in ethyl acetate, it ended up with Fe3O4. Among all the particles, those with a diameter of 200 nm have the highest temperature and undergo the phase transition first. The temperature of a 200 nm composite particle in ethanol is slightly lower than in ethyl acetate, i.e. 1870 K as compared to 1902 K. Phase equilibrium diagrams proved the existence of Fe, FeO, and Fe3O4 as the preferred phases at about 1900 K. Our research provides a new insight into the process of submicron particle formation during pulsed laser irradiation and allows proposing a mechanism for the growth of particles of different size and phase composition depending on the solvent.

Dataset Information

α-Fe₂O₃@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O₂ and imaging-guidance.

Publications

α-Fe<sub>2</sub>O<sub>3</sub>@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O<sub>2</sub> and imaging-guidance.

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