Topological Receptive Field Model for Human Retinotopic Mapping
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ABSTRACT:
SUBMITTER: Tu Y
PROVIDER: S-EPMC8570543 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Four right-handed, healthy subjects participated in a visual stimulation experiment. Subjects were viewing a dartboard-shaped flickering checkerboard stimulus, divided into 4 rings and 12 segments, defining 48 sectors in the visual field. Local contrast in each sector was continuously varying across four levels and updated every 3 s. To maintain fixation, subjects had to respond to a stimulus at the center of the visual field. During the entire experiment, in which subjects performed 8 runs, each consisting of 100 trials, brain activity was measured with functional magnetic resonance imaging (MRI). Using a 3-T Siemens Trio MRI scanner, 220 echo-planar images were acquired in each run, with a repetition time of 1.5 s and voxel size of 3 x 3 x 3 mm. The dataset is publicly available from OpenNeuro and additionally includes region of interest maps for visual areas V1 to V4, left and right, obtained from another retinotopic mapping experiment. As such, the dataset allows for accurate mapping of receptive fields and their properties across several stages of human visual cortex.
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Project description:We introduce functional MRI methods for estimating the neuronal population receptive field (pRF). These methods build on conventional visual field mapping that measures responses to ring and wedge patterns shown at a series of visual field locations and estimates the single position in the visual field that produces the largest response. The new method computes a model of the population receptive field from responses to a wide range of stimuli and estimates the visual field map as well as other neuronal population properties, such as receptive field size and laterality. The visual field maps obtained with the pRF method are more accurate than those obtained using conventional visual field mapping, and we trace with high precision the visual field maps to the center of the foveal representation. We report quantitative estimates of pRF size in medial, lateral and ventral occipital regions of human visual cortex. Also, we quantify the amount of input from ipsi- and contralateral visual fields. The human pRF size estimates in V1-V3 agree well with electrophysiological receptive field measurements at a range of eccentricities in corresponding locations within monkey and human visual field maps. The pRF method is non-invasive and can be applied to a wide range of conditions when it is useful to link fMRI signals in the visual pathways to neuronal receptive fields.
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Project description:High-resolution functional MRI is a leading application for very high field (7 Tesla) human MR imaging. Though higher field strengths promise improvements in signal-to-noise ratios (SNR) and BOLD contrast relative to fMRI at 3 Tesla, these benefits may be partially offset by accompanying increases in geometric distortion and other off-resonance effects. Such effects may be especially pronounced with the single-shot EPI pulse sequences typically used for fMRI at standard field strengths. As an alternative, one might consider multishot pulse sequences, which may lead to somewhat lower temporal SNR than standard EPI, but which are also often substantially less susceptible to off-resonance effects. Here we consider retinotopic mapping of human visual cortex as a practical test case by which to compare examples of these sequence types for high-resolution fMRI at 7 Tesla. We performed polar angle retinotopic mapping at each of 3 isotropic resolutions (2.0, 1.7, and 1.1 mm) using both accelerated single-shot 2D EPI and accelerated multishot 3D gradient-echo pulse sequences. We found that single-shot EPI indeed led to greater temporal SNR and contrast-to-noise ratios (CNR) than the multishot sequences. However, additional distortion correction in postprocessing was required in order to fully realize these advantages, particularly at higher resolutions. The retinotopic maps produced by both sequence types were qualitatively comparable, and showed equivalent test/retest reliability. Thus, when surface-based analyses are planned, or in other circumstances where geometric distortion is of particular concern, multishot pulse sequences could provide a viable alternative to single-shot EPI.
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