Serum anti-SERPINE1 antibody as a potential biomarker of acute cerebral infarction.

ABSTRACT: The presence of disease-specific antigens and autoantibodies in the sera of patients with atherosclerosis-related diseases has been widely reported and is considered to result from inflammation of the arterial wall and the involvement of immune factors. The aim of this study was to identify a novel antibody in patients with ischemic stroke by serological identification of antigens using recombinant cDNA expression cloning from patients who had a transient ischemic attack (TIA). We identified the serpin peptidase inhibitor, clade E member 1 (SERPINE1), as a candidate antigen. The serum anti-SERPINE1 antibody levels quantified using amplified luminescent proximity homogeneous assay-linked immunosorbent assay were significantly higher in patients with ischemic stroke, including those with acu

SUBMITTER: Kubota M 

PROVIDER: S-EPMC8571331 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature