Pleiotropic predisposition to Alzheimer's disease and educational attainment: insights from the summary statistics analysis.

ABSTRACT: Epidemiological studies report beneficial associations of higher educational attainment (EDU) with Alzheimer's disease (AD). Prior genome-wide association studies (GWAS) also reported variants associated with AD and EDU separately. The analysis of pleiotropic associations with these phenotypes may shed light on EDU-related protection against AD. We performed pleiotropic meta-analyses using Fisher's method and omnibus test applied to summary statistics for single nucleotide polymorphisms (SNPs) associated with AD and EDU in large-scale univariate GWAS at suggestive-effect (5 × 10^-8 < p < 0.1) and genome-wide (p ≤ 5 × 10^-8) significance levels. We report 53 SNPs that attained p ≤ 5 × 10^-8 at least in one of the pleiotropic meta-analyses and were reported in t

SUBMITTER: Kulminski AM 

PROVIDER: S-EPMC8572080 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature