Comparative Study of Human and Murine Aortic Biomechanics and Hemodynamics in Vascular Aging.

ABSTRACT: Introduction: Aging has many effects on the cardiovascular system, including changes in structure (aortic composition, and thus stiffening) and function (increased proximal blood pressure, and thus cardiac afterload). Mouse models are often used to gain insight into vascular aging and mechanisms of disease as they allow invasive assessments that are impractical in humans. Translation of results from murine models to humans can be limited, however, due to species-specific anatomical, biomechanical, and hemodynamic differences. In this study, we built fluid-solid-interaction (FSI) models of the aorta, informed by biomechanical and imaging data, to compare wall mechanics and hemodynamics in humans and mice at two equivalent ages: young and older adults. Methods: For the humans,

SUBMITTER: Hopper SE 

PROVIDER: S-EPMC8573132 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature