Ontology highlight
ABSTRACT:
SUBMITTER: Briquez PS
PROVIDER: S-EPMC8575143 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Briquez Priscilla S PS Rouhani Sherin J SJ Yu Jovian J Pyzer Athalia R AR Trujillo Jonathan J Dugan Haley L HL Stamper Christopher T CT Changrob Siriruk S Sperling Anne I AI Wilson Patrick C PC Gajewski Thomas F TF Hubbell Jeffrey A JA Swartz Melody A MA
medRxiv : the preprint server for health sciences 20211102
Patients infected with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can experience life-threatening respiratory distress, blood pressure dysregulation and thrombosis. This is thought to be associated with an impaired activity of angiotensin-converting enzyme-2 (ACE-2), which is the main entry receptor of SARS-CoV-2 and which also tightly regulates blood pressure by converting the vasoconstrictive peptide angiotensin II (AngII) to a vasopressor peptide. Here, we show that a si ...[more]