Variation of Genomic Sites Associated with Severe Covid-19 Across Populations: Global and National Patterns.

ABSTRACT:

Background

Information about the distribution of clinically significant genetic markers in different populations may be helpful in elaborating personalized approaches to the clinical management of COVID-19 in the absence of consensus guidelines.

Aim

Analyze frequencies and distribution patterns of two markers associated with severe COVID-19 (rs11385942 and rs657152) and look for potential correlations between these markers and deaths from COVID-19 among populations in Russia and across the world.

Methods

We genotyped 1883 samples from 91 ethnic groups pooled into 28 populations representing Russia and its neighbor states. We also compiled a dataset on 32 populations from other regions using genotypes extracted or imputed from the available databases. Geo

SUBMITTER: Balanovsky O 

PROVIDER: S-EPMC8575442 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature